Optical Coherence Tomography of the Airway in Detecting Abnormal Cells in Patients Undergoing Surgery for Lung Cancer or Lung Disease

Primary Outcome Measures:

• Correlation of optical coherence tomography images of the airway with airway histology [ Time Frame: This study will involve discarded tissue from 10 subjects with pathology specimens over one year. ] [ Designated as safety issue: No ]

Intervention Details:

Procedure: bronchoscopic and lung imaging studies

Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.

Procedure: diagnostic bronchoscopy

Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.

Procedure: histopathologic examination

All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

Procedure: optical coherence tomography

Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery.

Detailed Description

Objectives:

• Correlate optical coherence tomography images of the airway with airway histology.
• Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer.

Outline: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

Criteria

Disease Characteristics:

• Undergoing pneumonectomy or lobectomy for malignant or benign lung processes

Patient Characteristics:

• Not specified

Prior Concurrent Therapy:

• See Disease Characteristics