Mesothelioma
Adjuvant radiotherapy might not be the best treatment for mesothelioma sufferers because researchers at Duke and Stanford found that this therapy does not help patients live longer. The researchers analyzed a database of pleural mesothelioma patients at Duke and a national registry of patients. The research looked at the outcomes of patients with radiation after…
Primary Outcome Measures Number of Patients with Dose-limiting Toxicities [ Time Frame: Baseline up to 28 Days ] A DLT is defined as an AE that meets at least one of the criteria listed in protocol, according to National Cancer Institute (NCI) common terminology criteria for AE (CTCAE) version 5.0, and is considered by the investigator to be clinically…
Unfortunately for mesothelioma patients with high levels of the PD-L1 protein, they have a worse overall survival compared to patients who have lower levels. A European study looking at 200 patients wanted to see if PD-L1 and PD-1, popular targets for immunotherapy drugs, impact survival independently without immunotherapy drugs present. The researchers found that the…
A very aggressive mesothelioma treatment is proving to be more beneficial compared to just chemotherapy and surgery alone. The more aggressive therapy utilizes multiple techniques creating a more successful treatment in certain patients. Mesothelioma treatment needs to be aggressive because it is a tough to treat and aggressive cancer. People diagnosed typically only live a…
Researchers at the Hyogo College of Medicine have found that pleurectomy/decortication surgery can improve quality of life in mesothelioma patients, even if they have declining lung function. The researchers looked at 45 patients who received pleurectomy/decortication surgery between the years 2014 and 2018. After the patients received surgery, lung function tests showed that most of…
Primary Outcome Measures Number of patients with adverse events and serious adverse events [ Time Frame: 3 years ] Safety and tolerability of IAG933 Incidence of dose limiting toxicities during the first treatment cycle (dose escalation only) [ Time Frame: 1 year ] Safety, tolerability and the maximum tolerated dose or recommended dose of IAG933 Number of patients with dose interruptions and dose…
Japanese researchers have found that the main two types of surgery for mesothelioma have similar risks of death. The surgeries either remove the diseased lung lining and one of the lungs or just the lining. Doctors do not agree what surgery is best for mesothelioma patients, but both surgeries have their benefits and drawbacks. When…
Artificial intelligence could help treat mesothelioma in the future. Researchers in Scotland have been developing a prototype imaging system to help with diagnostics and therapeutics for the treatment of mesothelioma. It is being developed at the University of Glasgow and Canon Medical Research Europe. The artificial intelligence uses computer software to effectively detect and measure…
An Italian study has found that the combination of two immunotherapy drugs can create a long-term survival in mesothelioma patients. The two drugs, tremelimumab and durvalumab, were just given orphan drug status to treat liver cancer in the last year. The best results in the mesothelioma study were seen in patients with a high level…
Primary Outcome Measures Pre-treatment Prognostic Algorithm Validation [ Time Frame: 4 years ] The primary objective is to utilize a novel prognostic algorithm to predict the outcome of MPM patients. This algorithm includes 4 different tests: molecular, radiological, and blood based. It will be performed on 240 prospectively-collected samples. A score of 0-4 will be assigned to each patient…
