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Research at Temple University is looking at four different drug compounds, all used for noncancerous conditions, for treating mesothelioma. The research is part of a drug repurposing project, which tests drugs not typically used for illnesses like cancer to see if they work on the disease. Drug repurposing has become more popular over the years.…
Primary Outcome Measures The maximum tolerable dose (MTD) [ Time Frame: After two completed cycles of therapy (each cycle is 1 week) ] The primary endpoint of the study is to determine the maximum tolerable dose (MTD) of intraperitoneal (IP) paclitaxel monotherapy, for patients with malignant peritoneal mesothelioma (MPM) who are not eligible to undergo CRS-HIPEC. Secondary Outcome Measures…
Researchers may have found a better, less invasive way to test for mesothelioma. Normally, a biopsy is done, which requires removing tissue to diagnose mesothelioma, but a new two-part exam might make this procedure a thing of the past. The new test utilizes cytology, which looks at cells in body fluids, and immunology, which is…
Primary Outcome Measures Modification(s) in the immune blood markers of treated subjects on treatment. [ Time Frame: Assessment: between week 4 and 6 after the first dose of the treatment ] Modification(s) in the immune blood markers including cytokines, immune cells and serum autoantibody level of treated subjects. Modification(s) in the immune blood markers of treated subjects on treatment.…
Researchers are performing a clinical trial hoping that they can make pleural mesothelioma a more manageable, and even survivable, disease. The clinical trial is being done at Princess Margaret Cancer Center in Toronto. The trial is known as SMARTEST, which stands for Surgery for Mesothelioma After Radiation Therapy using Exquisite Systemic Therapy. Researchers in the…
Primary Outcome Measures Determination of ORR for the combination of OT-101 and pembrolizumab in subjects [ Time Frame: approximately 24 months ] modified RECIST (mRECIST; v1.1) Secondary Outcome Measures PFS, DOR and 6-month and 12-month Overall Survival (OS) will be estimated in all subjects in the ITT population. [ Time Frame: approximately 18 months ] Progression-free Survival (PFS), defined as the time from…
Promising results from a study on pleural mesothelioma were recently released. The study found when patients were treated with a new combination treatment, patients lived longer and had a better quality of life. The phase I clinical trial utilized a targeted cancer vaccine known as galinpepimut-S (GPS) and the immunotherapy drug Opdivo. SELLAS Life Sciences…
Growing levels of asbestos are coming into the United States, even though there is a push to tighten regulations and even ban the substance. The main user of asbestos, the chloralkili industry, imported around 114 metric tons of asbestos from January through March of 2022. This is much higher than the 100 metric tons of…
Primary Outcome Measures Dose-limiting Toxicity (DLT) [ Time Frame: 28 days ] DLTs will be assessed via CTCAE version 5.0 Inclusion Criteria Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 in dose escalation, 0 to 2 in dose expansion Has a life expectancy of >3 months Has a malignancy: with histologically or cytologically confirmed…
Over the past 20 years, the number of women dying from mesothelioma increased by 25 percent. This is happening even with less asbestos being used. Deaths in men have been falling, the reverse of what is happening in women. The information was published in the Morbidity and Mortality Weekly Report by the CDC. The annual…
