Cisplatin (Platinol ®)
When it comes to different treatments for mesothelioma patients, there is no shortage of diversity, as options include chemotherapy, radiation, surgery, immune-based therapies, gene-based therapies, and more. Chemotherapy treatments cisplatin and pemetrexed are first line treatments, especially among those who do not quality for surgery. Radiation treatment is available, but is typically the path less…
A Phase I study for cediranib, a VEGFR/PDGFR kinase inhibitor, showed promising results in shrinking tumor size and increasing survival rates for those suffering from malignant pleural mesothelioma. This is not the first time cediranib has been studied as a possible treatment for mesothelioma. In 2011/2012 a Phase II trial for cediranib conducted by researchers…
A biopharmaceutical company named Aduro Biotech recently announced its collaboration with Merck to further evaluate the findings for the Phase II trial of KEYTRUDA ® (pembrolizumab) and to combine their own immunotherapy treatment, CRS-207. Information regarding KEYTRUDA ® treatment began to circulate late last year when data presented at the 17th World Conference on Lung…
The results of a 2016 Phase III trial of the monoclonal antibody bevacizumab (Avastin) have established another option for treatment for those suffering from malignant pleural mesothelioma. Angiogenesis, which is the formation of new blood vessels, plays a key role in mesothelioma because it allows the tumors and cancer to spread. However, scientists and researchers…
Scientists and researchers are excited over the latest completion of a Phase II clinical trial for those suffering from mesothelioma – an incurable asbestos-caused cancer that has a median survival of only 9 to 12 months. The LUME-Meso Phase II trial for patients with malignant pleural mesothelioma showed a slight increase in progression-free and overall…
Malignant Pleural Mesothelioma (MPM) is a rare, aggressive asbestos –related cancer that has a poor survival rate due to the fact that the cancer is hard to detect early, and once detected, has usually spread and is hard to control. Surgery is typically an effective option for removing cancerous cells, but in some cases, surgery…
Combining different types of treatment when it comes to treating mesothelioma is common because of how aggressive the cancer can be. While some treatments do prove to be effective, the overall prognosis of an individual with this asbestos-related cancer remains dim. A recent study done in Korea carefully evaluated the combination of cisplatin, a common…
Understanding malignant mesothelioma and the way it develops is significant when discovering prevention, development control, and the eventual lead to a cure. Cancer researchers at the Mayo Clinic have been researching the genetic composition of the disease in hopes to find a connection between the development of mesothelioma and mutations in DNA. To find these…
Chemotherapy remains one of the most effective treatments for mesothelioma. Because there is no cure, it works to prolong the lives of patients. Unfortunately, even the most effective methods can become inadequate as treatments continue. A current clinical trial is attempting to extend the usefulness period of chemotherapy and in turn extend the lives of…
A recent mesothelioma study found the addition of bevacizumab to the chemotherapy treatment of pemetrexed plus cisplatin may increase the survival rate in patients. From 2008 to 2014, patients were given the standard treatment in 21-day increments for six cycles, with some receiving bevacizumab. The addition of bevacizumab increased survival to a median of 19.8…
