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New Treatments Target the Immune System of Victims of Mesothelioma
Mesothelioma, a rare and deadly cancer, is a cancer that affects the mesothelium, which is the lining that surrounds internal organs. Pleural mesothelioma is cancer that appears in the lining of the lungs, and accounts for about 75% of all mesothelioma cases. Aggressive cancers such as mesothelioma take a toll on the victim’s immune system,…
Read MoreScreening of Alberta Asbestos Exposed Workers for Lung Cancer and Mesothelioma
Purpose:Asbestos defines a group of naturally occurring mineral silicate fibers which are easily inhaled, resulting in a variety of diseases of the respiratory system including lung cancer and malignant mesothelioma. Despite some advances in treatment, there has been little impact on overall survival for both lung cancer and mesothelioma in the past 20 years in great part because patients usually present with disease at an advanced and incurable stage. This study aims to develop and implement a low-dose computed tomography (LDCT) screening approach for lung cancer and mesothelioma in asbestos-exposed workers in Alberta.
Read MoreIntrapleural Administration of HSV1716 to Treat Patients With Malignant Pleural Mesothelioma
Purpose:HSV1716, an oncolytic virus, is a mutant herpes simplex virus (HSV) type I, deleted in the RL1 gene which encodes the protein ICP34.5. Malignant mesothelioma is an aggressive, asbestos-related tumour of the pleural and peritoneal cavities. It is a rare cancer which occurs in individuals who have been exposed to asbestos, although it typically occurs decades after exposure (10-40 years later). Malignant pleural mesothelioma forms plaques that are distributed on the surface of the pleural space in the lung. Approximately 30% of patients require an indwelling pleural catheter for drainage of pleural effusions. In this patient group, the indwelling catheter may be used to facilitate loco-regional delivery of HSV1716 to the pleural space. This study seeks to evaluate the safety and biological effects of single and multiple administrations of HSV1716 in the treatment of malignant pleural mesothelioma.
Read MoreTransarterial Chemoperfusion: Cisplatin, Methotrexate, Gemcitabine for Unresectable Pleural Mesothelioma
Purpose:The purpose of this study is to determine whether the transarterial chemoperfusion treatment with cisplatin, methotrexate and gemcitabine is safe and effective in adults with malignant pleural mesothelioma (MPM).
Read MorePositive Genetic Studies and Treatment for Mesothelioma Patients
Understanding malignant mesothelioma and the way it develops is significant when discovering prevention, development control, and the eventual lead to a cure. Cancer researchers at the Mayo Clinic have been researching the genetic composition of the disease in hopes to find a connection between the development of mesothelioma and mutations in DNA. To find these…
Read MoreEfficacy and Safety of PIPAC/PITAC in Gastric,Ovarian, Colorectal Cancer and Mesothelioma With Pleural Carcinomatosis. (PIPAC/PITAC)
Purpose:Outcome measurement for patients with gastric, ovarian, colorectal, or pleural cancer/mesothelioma with peritoneal/pleural carcinomatosis undergoing pressurized intraperitoneal/intrathoracal aerosol chemotherapy (PIPAC/PITAC) with cisplatin and doxorubicin or oxaliplatin. Record of (partial/total) tumor response rate via survival rate, time until tumor progression (according to RECIST-criteria), peritoneal carcinomatosis index (PCI) before and after therapy, histological tumor progression/regression, ascites/pleural affusion volume, degree of tumor cell apoptosis.
Read MoreExciting New Developments in Research and Technology Regarding Mesothelioma and Lung Cancer
Mesothelioma, a cancer caused by asbestos exposure, is rare, aggressive and fatal. Researches are discovering more and more about this disease daily, and with that, they are one step closer to finding more effective treatments. In a most recent study, scientists looked into why, after initial treatments, the cancer cells become immune to the chemotherapy,…
Read MoreDo Your Genes Put You at a Higher Risk of Developing Mesothelioma
Purpose: The purpose of this research study is to investigate the possibility that a person’s genes put a person at a higher risk of developing mesothelioma. The investigators will examine genes from DNA (genetic material) isolated from blood. This study will also examine the impact of environmental and work exposures and family history of common cancers on the development of mesothelioma. The genetic markers in this study will basically identify how a person’s body processes frequently encountered environmental pollutants and will not tell about chromosomes, specific diseases, or other potential health problems.
Read MoreThe use of asbestos to create picture perfect snow
In 2015, we’re well aware of the dangers associated with asbestos, a naturally occurring fibrous mineral. Decades ago, the mineral was used in cigarettes, insulation and roofing due to its flame-resistant capabilities, but it also had more commercial uses. The light, white and fluffy nature of the fibers made it perfect for creating artificial snow. Prior…
Read MorePemetrexed Disodium/Observation in Treating Patients W/ Malignant Pleural Mesothelioma w/Out Progressive Disease After 1st Line Chemotherapy
Purpose: This randomized phase II trial is studying how well pemetrexed disodium or observation works in treating patients with malignant pleural mesothelioma without progressive disease after first-line chemotherapy.
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