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Mithramycin for Lung, Esophagus, and Other Chest Cancers
Purpose: Mithramycin is a drug that was first tested as a cancer therapy in the 1960s. It acted against some forms of cancer, but was never accepted as a treatment. Research suggests that it may be useful against some cancers of the chest, such as lung and esophageal cancer or mesothelioma. Researchers want to see if mithramycin can be used to treat these types of cancer.
Objectives
To see if mithramycin is safe and effective against different chest cancers.
Design
Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. Imaging studies and tumor tissue samples will be used to monitor the cancer before treatment.
Participants will receive mithramycin every day for 7 days, followed by 7 days without treatment. Each
Treatment will be monitored with frequent blood tests and imaging studies.
Participants will continue to take the drug for as long as the side effects are not severe and the tumor responds to treatment.
Rapid Autopsy and Procurement of Non-Small Cell Lung Cancer Tissue
Purpose: People with lung cancers unfortunately commonly succumb to their disease. Some agree to donate their bodies to cancer research that may help the medical community better understand these diseases. Studies of lung cancer tumor tissue obtained soon after death may be used to answer questions about the origins, progression, and treatment of lung cancer. Researchers want to conduct a study that involves planned collection of lung cancer tumor tissue shortly after death. To do so, they will arrange to provide inpatient hospice care for people with non-small cell lung cancer.
Read MorePtac2S Potentially More Effective Than Cisplatin When Fighting Mesothelioma
Malignant Pleural Mesothelioma (MPM) is a rare, aggressive asbestos –related cancer that has a poor survival rate due to the fact that the cancer is hard to detect early, and once detected, has usually spread and is hard to control. Surgery is typically an effective option for removing cancerous cells, but in some cases, surgery…
Read MoreMEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma
PurposeThe objective of this study is to determine whether MEDI4736 or combination therapy with MEDI4736 + tremelimumab are associated with favorable alterations of the intratumoral immunologic environment in subjects undergoing resectional surgery for Malignant Pleural Mesothelioma MPM.
Read MoreIntrapleural Cryotherapy for Malignant Pleural Mesothelioma
Purpose: an neoadjuvant intrapleural cryotherapy be safely performed in patients with malignant pleural mesothelioma and will it trigger substantial systemic and local pro-inflammatory changes, resulting in the induction of anti-tumor immunity?
Read MoreProperties in Red Wine Could Help Fight Mesothelioma
Combining different types of treatment when it comes to treating mesothelioma is common because of how aggressive the cancer can be. While some treatments do prove to be effective, the overall prognosis of an individual with this asbestos-related cancer remains dim. A recent study done in Korea carefully evaluated the combination of cisplatin, a common…
Read MoreStaging Procedures to Diagnose Malignant Pleural Mesothelioma
Purpose: The purpose of this study is to evaluate the accuracy of participants imaging versus staging procedures. The investigators will consent subjects that are scheduled to undergo staging procedures to diagnose malignant pleural mesothelioma (including pleuroscopy, bronchoscopy, endobronchial ultrasound and laparoscopy) as part of their standard of care.
Read MoreThe Introduction of the Alan Reinstein Ban Asbestos Now Act of 2016, S.3427
The Alan Reinstein Ban Asbestos Now Act of 2016 S.3427 was introduced to the Senate on September 28, 2016. Supported by Senator Barbara Boxer, this bill was read and referred to the Committee on Environment and Public Works. Its purpose is to amend the Toxic Substances Control Act (TSCA) to potentially have asbestos banned in…
Read MoreConcurrent Pemetrexed/Cisplatin With Pleural Intensity Modulated Radiation Therapy for Patients With Unresectable Malignant Pleural Mesothelioma
PurposeThe purpose of this study is to evaluate the safety of combining chemotherapy at different doses with a specific type of radiation therapy delivered to the entire lining of the lung to find out what effects, if any, it has on people. This radiation technique is called pleural intensity modulated radiation therapy (IMRT). IMRT specifically targets the lining of the lung (pleura) where the cancer is and reduces the risk of damaging the lung itself. When given after chemotherapy, pleural IMRT has demonstrated promising results with respect to keeping mesothelioma under control longer. However, the investigators want to determine if giving pleural IMRT at the same time as chemotherapy is safe. If safe, further studies will be done to see if chemotherapy and pleural IMRT given at the same time keeps the tumor under control for a longer period of time than chemotherapy followed by pleural IMRT.
Read MoreAsbestos Exposure – Can We Really Control It?
Asbestos is typically thought of as a substance that is no longer in use anymore because it is a well-known carcinogen. Asbestos is fire resistant, strong, cheap, abundant, and absorbs sound. It is no wonder it rose to popularity throughout the 20th century since it was so versatile. While asbestos is solid rock, it is…
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